Not Much Drinking Required

...street name rhino tranq, a nonopioid tranquilizer with roots in veterinary medicine that somehow found its way into the illegal drug supply in many American cities-- most prominently Philadelphia, but also reportedly identified in Baltimore, Washington DC, Chicago, Detroit, and St. Louis, among others.

Here’s something on the spread of rhino tranq in the Northeast:

A Powerful New Drug Is Creating a ‘Withdrawal Crisis’ in Philadelphia

Like its relative xylazine, medetomidine is especially dangerous to humans when found with fentanyl. A fentanyl overdose can usually be reversed by naloxone, but where medetomidine is present, the risk of death continues.

Then there is the issue of physical dependence and a dangerous, perhaps even life-threatening withdrawal syndrome, if use of the drug is abruptly ceased without benefit of a taper.

According to the literature, medetomidine withdrawal can precipitate "tachycardia, severe hypertension, waxing and waning...