The first trials did not demonstrate effectiveness beyond placebo. So the FDA allowed a third trial which apparently did, at least a little.
The physician, meanwhile, depends on the information provided by medical science, usually in the form of materials from the pharma firm that markets the product.
My concern is that these same hallucinogens have a pronounced tendency to escape the research environment and find their way out into the streets
In the absence of complaints, the prescriber can be tempted to assume things are going well, when in fact they aren’t.
Patients with severe substance disorders may experience depression as a result of the cumulative effects of their substance use.
It’s an illness that at different times seems to respond to everything and nothing. As in ‘everything works for someone, and nothing works for everyone.’
The better we understand the origins of a depressed mood, the more likely we are to come up with an effective remedy.
There’s plenty of evidence that treatment for depression works, and that people with co-occurring disorders can and do get a whole lot better.