Legalization solves problems related to the legal status of a drug, but has far less impact on the problems related to the nature of the substance itself.
There is research that links more potent cannabis, including skunk, to THC-related changes in the brain, among daily users at least.
That we have such a large and growing community of frequent users is a tribute not to evidence, but to hype.
Cannabis doesn’t replace opioids the way methadone or buprenorphine do. There’s no antagonist effect as with naloxone or naltrexone.
The best answer is the one we came up with to explain the selectivity of alcoholism: Differences in individual susceptibility.
There’s not a lot of disagreement about the potential for cannabis intoxication to impair driving performance, though without an accepted standard and a reliable roadside test, it’s not of much value in a courtroom.
Unbeknownst to the patient, the CBD products they also use could affect how well those prescribed medicines work, or interact with them in unhelpful ways.
It’s likely that certain individuals are vulnerable to psychosis, and experts may point to a family history of mental illness.
I think the problem is I have read the research, and it didn’t confirm the claims made on its behalf.