I was surprised to learn that the antidepressant effects of ketamine were completely blocked by naltrexone, an opioid antagonist. That certainly suggests ketamine is making use of the brain’s opioid systems…
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“How many fewer days?” was my question. Looks like about 10%.
So if the subject ordinarily drank every day, they eliminated one drinking day in ten?
Originally developed to replace PCP as a fast-acting anesthetic, it quickly morphed into a party drug, then as another product sold in street drug markets.
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Excited delirium is a term widely recognized in emergency medicine yet somehow lacks a single accepted definition.
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The first trials did not demonstrate effectiveness beyond placebo. So the FDA allowed a third trial which apparently did, at least a little.
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