There is research that links more potent cannabis, including skunk, to THC-related changes in the brain, among daily users at least.
That we have such a large and growing community of frequent users is a tribute not to evidence, but to hype.
The first trials did not demonstrate effectiveness beyond placebo. So the FDA allowed a third trial which apparently did, at least a little.
The list of deaths from the practice is long and oddly prestigious, featuring celebs such as John Belushi and Chris Farley, among many others.
If the dose is in fact subtherapeutic, then what causes the effects so enthusiastically reported by the user?
The best answer is the one we came up with to explain the selectivity of alcoholism: Differences in individual susceptibility.
Will society benefit from greater access to this drug? Are there potential problems we haven’t anticipated?
Unbeknownst to the patient, the CBD products they also use could affect how well those prescribed medicines work, or interact with them in unhelpful ways.