The relative importance of set and setting suggests that the environment in an LSD experience should be carefully controlled.
I recall several cases admitted to the inpatient psych ward at one hospital where I worked in Boston, usually with severe psychotic symptoms.
My concern is that these same hallucinogens have a pronounced tendency to escape the research environment and find their way out into the streets
It’s the sort of evidence that convinced authorities to greatly expand access to opioids for chronic pain patients.
Something about this class of drugs appears to turn some scientists into the equivalent of helpless fanboys.
Some of the adverse effects reported by K2 and Spice users are no doubt related to unidentified substances that adulterate the product.
I think the continuing popularity of substance use through the ages is because in practical terms, substances work.